zika virus serologic Properties

Zika virus has been misdiagnosed as dengue because of similar clinical symptoms and serologic cross-reactivity with DENVs. In article named "Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007", the serologic data indicate that ZIKV-infected patients can be positive in an IgM assay for DENVs, particularly if ZIKV is a secondary flavivirus infection. In contrast to primary flavivirus/ZIKV–infected patients, secondary flavivirus–infected patients showed a high degree of serologic cross-reactivity with other flaviviruses.

IgM antibody response in primary flavivirus/ZIKV–infected patients is specific for ZIKV. PRNT90 results also showed that the neutralizing antibody response among primary flavivirus/ ZIKV–infected patients is highly specific. If ZIKV is the first flavivirus encountered, data indicates that cross-reactivity is minimal.

Levels of viremia among ZIKV-infected patients were relatively low. And, Nucleic acid sequence of ZIKV 2007 showed divergence (11%) from the prototype strain (MR766) isolated in 1947. However, the predicted amino acid sequence is fairly conserved (96%), which is likely the result of the selective pressure maintained on the virus because replication occurs in vertebrate hosts and arthropod vectors.

Zika virus reasearch reagents

--ZIKV-C
--ZIKV-PrM and E
--ZIKV NS1
--ZIKV NS3
--ZIKV-NS5
--ZIKV-E

Zika virus and cytokines
Zika virus and host receptors
What is Zika virus
What is Zika virus disease
Zika virus virology
Zika virus serologic properties
Zika virus symptoms
Zika virus transmission
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Zika virus vaccines
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Zika virus genome
Zika virus nucleotide
Zika virus geographic expansion
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