What is Enterovirus 71 (EV71)?

Enterovirus 71 (EV71), first isolated in California in 1969, is a member of human enterovirus species A, belongs to genus Enterovirus, family Picornaviridae. It is a small non-enveloped virus with viral particle size about 30 nm in diameter. Infections of enterovirus 71 / EV71 occur mainly in children, and commonly result in mild and self-limiting hand, foot, and mouth disease (HFMD).

However, severe neurological complications such as poliolike paralysis, aseptic meningitis, and encephalitis may be caused by enterovirus 71 / EV71 acute infections in young children, especially those less than 5 years old. This virus is transmitted through the fecal-oral route, and it is largely replicated in the tonsils and intestinal lymphoid tissue. Thus, the spread of the virus from a patient's gastrointestinal tract can last for several weeks. It is also possible that enterovirus 71 / EV71 may reach the central nervous system (CNS) by penetrating the blood-brain barrier somehow or by a neuronal route. During the past five decades, there have been a number of enterovirus 71 / EV71 outbreaks worldwide, though countries in Asia-Pacific area are seriously affected in the last twenty years. Since no effective vaccine or approve antiviral agents has been developed, enterovirus 71 / EV71 becomes an important and emerging threat to public health.

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What is Enterovirus 71 (EV71)? Biological Characteristics of Enterovirus 71 (EV71)
Genetic Variations of Enterovirus 71 (EV71) Clinical Development of Enterovirus 71 (EV71) Vaccine
Potential Drug Targets of Enterovirus 71 (EV71)  
EV71 Virus Protein

Enterovirus VP0 Protein & Antibody

EV71 Strain Source

Strain BrCr

EV71 Infection Receptor

CyPA / PPIA
Vimentin / VIM
FABP1 / L-FABP
FABP2 / I-FABP
hnRNP K / HNRNPK
PSGL-1 / CD162
SCARB2 / LAMP-2

EV71 Information

What is Enterovirus 71 (EV71)
Biological Characteristics of Enterovirus 71 (EV71)
Genetic Variations of Enterovirus 71 (EV71)
Clinical Development of Enterovirus 71 (EV71)
Potential Drug Targets of Enterovirus 71 (EV71)

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EV 71 (Human Enterovirus 71)
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