Anti-VSIG4 Antibody

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Anti-VSIG4 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-VSIG4 Antibody
Validated applications
ELISA(Cap)
Species reactivity
Reacts with: Human
Specificity
Human VSIG4
Immunogen
Recombinant Human VSIG4 Protein (Catalog#12163-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human VSIG4 (rh VSIG4; Catalog#12163-H08H; Q9Y279-1; Met1-Pro283).
Source
Monoclonal Rabbit IgG Clone #202
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-VSIG4 Antibody (Rabbit Monoclonal antibody) Validated Applications

Notes
ELISA(Cap): This antibody will detect Human VSIG4 in ELISA pair set (Catalog: # SEK12163). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 12163-R005).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-VSIG4 Antibody: Alternative Names

Anti-CRIg Antibody; Anti-Z39IG Antibody

VSIG4 Background Information

VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type Ig domain and a truncated C-type Ig domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 28 amino acid precursor that contains a signal sequence, an V-type Ig domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type Ig domain of mouse VSIG4 shares 86% and 8% aa sequence identity with the V-type Ig domains of rat and human VSIG4, respectively.
Full Name
V-set and immunoglobulin domain containing 4
References
  • Vogt, L. et al., 2006, J Clin Invest.116: 2817-2826.
  • Helmy, K. et al., 2006, Cell. 124:915-927.
  • Wiesmann, C. et al., 2006, Nature. 444:217-220.
  • Zang,X. et al., 2006, J Clin Invest. 116: 2590-2593.
  • Katschke, KJ. et al., 2007, J. Exp. Med. 204:1319-1325.
  • He,JQ. et al., 2008, Mol Immunol. 45: 4041-4047.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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