SLITL2 / VASN: SLITL2 / VASN Protein | SLITL2 / VASN Antibody

SLITL2 / VASN Background

Vasorin is a typical type I membrane protein. It contains 1 EGF-like domain, 1 fibronectin type-III domain, 1 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. Vasorin is predominantly expressed in vascular smooth muscle cells, and that its expression is developmentally regulated. vasorin It directly binds to transforming growth factor (TGF)-β and attenuates TGF-β signaling in vitro. This suggests that down-regulation of vasorin expression contributes to neointimal formation after vascular injury and that vasorin modulates cellular responses to pathological stimuli in the vessel wall.

Reference for SLITL2 / VASN

  • Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14(10B):2121-7.
  • Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 44(2):325-40.
  • Lee KA, et al. (2011) Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. J Biol Chem. 286(48):41530-8.

SLITL2 / VASN Protein

SLITL2 / VASN protein function

May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}.

SLITL2 / VASN protein expression

Tissue specificity

Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.

SLITL2 / VASN protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    673.00
  • Mass (Da)
    71.00

SLITL2 / VASN Antibody

There are 6 SLITL2 / VASN antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Cap), ELISA(Det). There are 5 SLITL2 / VASN antibody for ELISA, 1 SLITL2 / VASN antibody for ELISA(Cap), 1 SLITL2 / VASN antibody for ELISA(Det). Among all these SLITL2 / VASN antibodies, there are 2 anti-SLITL2 / VASN mouse monoclonal antibodies , 2 anti-SLITL2 / VASN rabbit monoclonal antibodies , 2 anti-SLITL2 / VASN rabbit polyclonal antibodies . All the SLITL2 / VASN anbodies are produced in house and all are in stock. SLITL2 / VASN antibody customerized service is available.

SLITL2 / VASN Gene

VASN gene / cDNA is a protein-coding gene which located on 16p13.3. The VASN gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.194 organisms have orthologs with human gene VASN.