tyrosine-kinase like group of kinases-enzyme

Tyrosine kinase-like (TKL) kinases are a diverse group of serine-threonine protein kinases with sequence similarity to tyrosine kinases (TK) but lacking TK-specific motifs. The TKL group is the most recently-defined and most diverse of the standard kinase groups. Families within the group are relatively weakly related to each other. Over half of plant kinomes is made of TKL kinases, and they include receptor kinases and possible tyrosine-specific kinases in other lineages.

Prominent mebers are the the Raf family kinases, acting as important components of the MAP kinase pathway, and TGF beta receptors involved in in many cellular processes such as cell growth, cell differentiation and apoptosis. In animals, TKLs are tightly integrated with other important signalling pathways and thus also play fundamental roles. For example, Mixed Lineage Kinases (MLKs) are known to be responsible for activating apoptotic pathways implicated in the pathogenesis of Parkinson disease. The inhibitor CEP-1347 inhibits MLKs to enhance neuronal survival in a number of clinical models and has entered clinical trials. The TGFβ type-I receptor activin receptor-like kinase 1 (ALK1, a TKL kinase) and its co-receptor endoglin play fundamental roles in angiogenesis and vascular development. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells.

IRAK Family
IRAK1BP1 IRAK2 IRAK3/IRAKM
IRAK4    
MLK Family
ILK/Integrin Linked Kinase LZK/MAP3K13 TAK1/MAP3K7
MLK3/MAP3K11 ZAK  
RIPK Family
RIPK1/RIP1 RIPK2/RIP2 RIPK3
RIPK4    
STKR Family
ALK-1/ACVRL1 ALK-2/ACVR1 ALK-3/BMPR1A
ALK-4/ACVR1B ALK-5/TGFBR1 ALK-6/BMPR1B
ALK-7/ACVR1C TGFBR2
Other Family
ACVR2B/Activin RIIB ACTR2/Arp2 BMPR2
KSR2 LIMK2  
Enzymes | Proteases | Kinases
Proteases products center
kinase products center
Protein Kinase Introduction
Protein kinase classified by catalytic domains
Protein kinase classified by substrates+
- Tyrosine Kinase
- tyrosine-kinase like group of kinases
- Receptor Tyrosine Kinase (RTKs)
- Non-Receptor Tyrosine Kinase (PTKS)
- Serine Threonine Kinase
- Histidine Kinase-HK
Protein Kinase Inhibitor
Dual specificity kinase
Intracellular Kinases
Protein kinase related to signaling pathway
Protein Kinase in the Akt Pathway
Protein Kinase in Apoptosis Regulation
Lipid Kinase
Other Enzymes products center