Tumor Necrosis Factor Receptor / TNF Receptor

As a member of cytokine receptors, TNF receptors are typically expressed as trimeric type I transmembrane proteins and contain one to six cysteine-rich domains (CRDs) in their extracellular domain. TNF receptors are involved in diverse biological processes ranging from the selective induction of cell death in potentially dangerous and superfluous cells to providing costimulatory signals that help mount an effective immune response.

Different forms of tumor necrosis factor (TNF) interact with two specific receptors for TNF receptor (TNFR) on the cell membrane to induce a variety of effects. While sharing structural similarities in their extracellular domains, the two TNF receptors differ in their intracellular domain, their signal transduction, and consequently their function.

In addition, tumoral necrosis factor α plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti TNF drugs / agents has turned into the most important tool in the management of a variety of disorders, such as rheumatoid arthritis, spondyloarthropatties, inflammatory bowel disease, and psoriasis. Learn more about targeted therapy.

tnf receptor

TNF Receptor Molecules List

TRAF1 TRAF2 TRAF3 / CD40BP
TRAF3IP1 TRAF4 TRAF7
TRAP1 TNFR1/TNFRSF1A/CD120a TRAP100/MED24
TNFR2/TNFRSF1B/CD120b LTBR/TNFRSF3 OX40/TNFRSF4/CD134
CD40/TNFRSF5 DcR3/TNFRSF6B CD27/TNFRSF7
CD30/TNFRSF8 4-1BB/TNFRSF9/CD137 TRAIL R1/CD261/TNFRSF10A
TRAIL R2/CD262/TNFRSF10B TRAILR3/TNFRSF10C TRAIL R4/CD264/TNFRSF10D
TNFRSF11A Osteoprotegerin/TNFRSF11B TNFRSF12A/FN14/TWEAKR
TACI/TNFRSF13B(CD267) BAFFR / TNFRSF13C / CD268 HVEM/TNFRSF14/CD270
BCMA/TNFRSF17/CD269 GITR/TNFRSF18/CD357 RELT/TNFRSF19L
TNFRSF19/TROY TNFRSF21/DR6 TNFRSF25/DR3/TNFRSF12
Receptors
Receptors Classification
What are Receptors
Cytokine Receptors+
- Chemokine Receptor
- IFN Receptor
- TNF Receptor
- CSF Receptor
- Interleukin Receptor
- TGF-beta Superfamily Receptors
Growth Factor Receptors
Fc Receptor / FcR
Receptors by Differentiation Cells
Receptors by Functions
Receptors Reagent Products
Receptors by Species