Therapeutic Target of Complement System

Serine Protease Inhibitors as Therapeutic Target of Complement System

Soluble Complement Regulators as Therapeutic Target of Complement System

Other Related Research Areas

Therapeutic Target of Complement System Background

Today it is clear that complement system is a key player of the innate immune system. However, this integral position in the maintenance and regulation of immune and inflammation reactions also makes it a trigger point for a variety of pathologic conditions. Erroneous activation or insufficient regulation of the complement cascade may turn its destructive actions against the host’s cells. As a consequence, many inflammatory and autoimmune diseases are thought to be caused, or at least supported, by unleashed complement. Inhibition or modulation of complement system has therefore been recognized as a promising therapeutic target for many years.

However, successful marketing of complement-targeted drugs has proved to be more difficult than initially expected, and many strategies have been discontinued. The US Food and Drug Administration’s approval of the first complement-specific drug, an antibody against complement component C5 (eculizumab; Soliris), in March 2007, was a long-awaited breakthrough in the field. Approval of eculizumab validates the complement system as therapeutic target and might facilitate clinical development of other promising drug candidates.

Therapeutic Target of Complement System References

1. Ricklin D, et al. (2007). Complement-targeted therapeutics. Nature biotechnology, 25(11), 1265-1275.
2. Hajishengallis G, et al. (2013). Complement-targeted therapeutics in periodontitis. In Complement Therapeutics (pp. 197-206). Springer US.

Complement System
Complement System Overview
Complement System Component / Protein Regulator and Receptor
Complement Genetic Feature
Complement Activation Pathways
Complement System Role
Complement System and Direct Interactions+
- Mannose Binding Lectin/MBL
Complement System Function in Immune System+
- Complement System in Adaptive Immunity
- Complement System in Innate Immunity
Complement-Dependent Cytotoxicity/CDC+
- Complement-Dependent Cytotoxicity/CDC Crossmatch
Therapeutic Target of Complement System+
- Serine Protease Inhibitors as Therapeutic Target of Complement System
- Soluble Complement Regulators as Therapeutic Target of Complement System
- Complement Component Inhibitors as Therapeutic Target of Complement System
- Anaphylatoxin Receptor Antagonists as Therapeutic Target of Complement System
- Therapeutic Antibodies of Complement System
Complement System and Toll-like Receptors / TLRs
Complement System and Coagulation
Complement Cascade and Inhibitors
Complement Evasion of Pathogens
Complement System and Antimicrobial Peptides/AMPs
Complement System and Diseases
Complement System Deficiency Diseases
Complement System Structure
Complement System Effector Functions
Anti-Complement Antibody Products