TGF-beta Superfamily Receptors

TGF-beta superfamily receptors are a family of cell surface serine/threonine kinase receptors, including TGF-beta family receptor, bone morphogenetic protein receptor (BMP receptor), glial cell line-derived neurotrophic factor receptor (GDNF receptor), activin receptor and others.

TGF-beta superfamily receptors signal through cell-surface serine/threonine kinase receptors to the intracellular Smad proteins, which in turn accumulate in the nucleus to regulate gene expression. TGF-beta superfamily, found in both vertebrates and invertebrates, are ubiquitously expressed in diverse tissues and function during the earliest stages of development and throughout the lifetime of animals. Indeed, it has been demonstrated that key roles in embryonic stem cell self-renewal, gastrulation, differentiation, organ morphogenesis, and adult tissue homeostasis.

TGF-beta Superfamily Receptors Products List

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ACVR2A ACVR2B/Activin RIIB ALK-1/ACVRL1
ALK-2/ACVR1 ALK-4/ACVR1B ALK-3/BMPR1A
IALK-6/BMPR1B BMPR2 GFRA1
GFRA2 GFRA3 NCAM1 / CD56
NCAM2 / Neural cell adhesion molecule ALK-7 / ACVR1C ATF2
Cripto/TDGF1/ CRGF Endoglin/CD105 TGFBR1 / ALK-5
TGFBR2 TGFBR3 / Betaglycan  
Receptors
Receptors Classification
Cytokine Receptors+
- Chemokine Receptor
- IFN Receptor
- TNF Receptor
- CSF Receptor
- Interleukin Receptor
- TGF-beta Superfamily Receptors
Activin Receptor
BMP Receptor
GDNF Receptor
TGF-beta Family Receptor
Receptors by Differentiation Cells
Receptors by Functions
Receptors Reagent Products
Receptors by Species