T cell is a type of lymphocytes that plays a key important role in adaptive immunity, which tailors the body's immune response to specific pathogens.
The T cell antigen receptor (TCR) is the principle defining marker of all T cells. Also associated with the TCR is a complex of proteins known as CD3, which participate in the transduction of an intracellular signal following TCR binding to its cognate MHC/antigen complex.
With the help of chemokine receptor CCR5 or CXCR4, HIV binds CD4 and penetrates its nucleic acid into the host cell. This cause CD4 T-cell destruction and immune system collapse.
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|GPR83||CD122 / IL-2RB||IL7R/IL-7R/CD127|
|CCR4/CD194||TLR1 / CD281||TLR2 (CD282)|
|TLR4 / TLR-4||TLR10||Frizzled-9/FZD9|
|TNFR1/TNFRSF1A/CD120a||TLR3 / CD283|