TRADD Gene Sequence, Family, Fuction and Expression Information

TRADD cDNA / Gene Overview

TRADD cDNA / gene is a gene with protein product which located on 16q22.1. The TRADD gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 238 organisms have orthologs with human gene TRADD.

TRADD cDNA / Gene Function

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

TRADD cDNA / Gene Sequence

LOCUS
HUMTRADD 1435 bp mRNA linear PRI 26-APR-1996
DEFINITION
Homo sapiens TNF receptor-1 associated protein (TRADD) mRNA, 3' end of cds.
ACCESSION
L41690
VERSION
L41690.1

This sequence information is just for reference only.

TRADD cDNA / Gene Alias

  • Hs.89862

TRADD cDNA / Gene Expression

Ubiquitous expression in stomach (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues