Tissue Factor Gene Sequence, Family, Fuction and Expression Information
Tissue Factor cDNA / Gene Overview
F3 gene / cDNA is a protein-coding gene which located on 1p21.3. The F3 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.231 organisms have orthologs with human gene F3.
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Tissue Factor cDNA / Gene Sequence
LOCUS NM_001993 2393 bp mRNA linear PRI 29-JUL-2018
Homo sapiens coagulation factor III, tissue factor (F3), transcript variant 1, mRNA.
This sequence information is just for reference only.
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