Tissue Factor Gene Sequence, Family, Fuction and Expression Information

Tissue Factor cDNA / Gene Overview

F3 gene / cDNA is a protein-coding gene which located on 1p21.3. The F3 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.231 organisms have orthologs with human gene F3.

Tissue Factor cDNA / Gene Function

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Tissue Factor cDNA / Gene Sequence

LOCUS
LOCUS NM_001993 2393 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens coagulation factor III, tissue factor (F3), transcript variant 1, mRNA.
ACCESSION
NM_001993
VERSION
NM_001993.4

This sequence information is just for reference only.

Tissue Factor Family & Reagents

Gene family

Tissue Factor Gene family reagents (CD molecules)

Approved Symbol Reagent list
CDH1
FGFR4
ADGRE5
TNFSF4
NCAM1
ICAM1
CD58
LAMP2
CDCP1
CSF2RB
Approved Symbol Reagent list
CD209
PRNP
FCRL1
CD40LG
FZD10
HAVCR1
BST2
IFNGR1
TLR3
CD274

Tissue Factor cDNA / Gene Alias

  • CD142
  • TF
  • tissue factor

Tissue Factor cDNA / Gene Expression

Ubiquitous expression in placenta (RPKM 54.0), gall bladder (RPKM 41.2) and 22 other tissues

Recombinant Tissue Factor protein citations

Title
Participation of Extracellular Vesicles from Zika-Virus-Infected Mosquito Cells in the Modification of Naïve Cells' Behavior by Mediating Cell-to-Cell Transmission of Viral Elements
Year
2020
Author
Martínez-Rojas, PP;Quiroz-García, E;Monroy-Martínez, V;Agredano-Moreno, LT;Jiménez-García, LF;Ruiz-Ordaz, BH;
Journal
Cells
Title
Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles
Year
2020
Author
Camps, J;Breuls, N;Sifrim, A;Giarratana, N;Corvelyn, M;Danti, L;Grosemans, H;Vanuytven, S;Thiry, I;Belicchi, M;Meregalli, M;Platko, K;MacDonald, ME;Austin, RC;Gijsbers, R;Cossu, G;Torrente, Y;Voet, T;Sampaolesi, M;
Journal
Cell Rep
Title
Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles
Year
2020
Author
Camps, J;Breuls, N;Sifrim, A;Giarratana, N;Corvelyn, M;Danti, L;Grosemans, H;Vanuytven, S;Thiry, I;Belicchi, M;Meregalli, M;Platko, K;MacDonald, ME;Austin, RC;Gijsbers, R;Cossu, G;Torrente, Y;Voet, T;Sampaolesi, M;
Journal
Cell Rep