SMAC Protein Overview: Sequence, Structure, Function and Protein Interaction

SMAC Protein Overview

SMAC protein name

Recommended name
Diablo homolog, mitochondrial
Aliases
DFNA64, DIABLO-S, FLJ10537, FLJ25049, second mitochondria-derived activator of caspase, SMAC
Alternative name
Direct IAP-binding protein with low pI Second mitochondria-derived activator of caspase Smac

SMAC Protein Sequence

Species Human SMAC protein
Length 239
Mass (Da) 27131
Sequence Human SMAC protein sequence
Species Mouse SMAC protein
Length 237
Mass (Da) 26820
Sequence Mouse SMAC protein sequence
Species
Length
Mass (Da)
Sequence

SMAC Protein Molecular Weight & PI

Diablo homolog, mitochondrial precursor (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 56-239 Diablo homolog, mitochondrial.

Molecular weight (Da)

20765.16

Theoretical pI

4.78

SMAC Protein Structure

Structure of the BIR domain of IAP-like protein 2
Deposited
2004-08-27   Released:  2004-11-02
Deposition Author(s)
Shin, H., Renatus, M., Eckelman, B.P., Nunes, V.A., Sampaio, C.A.M., Salvesen, G.S.
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.2000 Å
R-Value Free
0.244
R-Value Work
0.223
1XB0 From PDB

Human SMAC protein Secondary structure

SMAC Protein Interaction

Recombinant SMAC Protein Feature

SMAC Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.
High Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant human SMAC-His (Cat:10339-H08E)at 10 μg/ml (100 μl/well) can bind recombinant human XIAP-AVI (Cat:10606-H17E) with a linear range of 0.125-1.0 μg/ml.

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