SMAC Protein Overview: Sequence, Structure, Function and Protein Interaction

SMAC Protein Overview

SMAC protein name

Recommended name
Diablo homolog, mitochondrial
DFNA64, DIABLO-S, FLJ10537, FLJ25049, second mitochondria-derived activator of caspase, SMAC
Alternative name
Direct IAP-binding protein with low pI Second mitochondria-derived activator of caspase Smac

SMAC Protein Sequence

Species Human SMAC protein
Length 239
Mass (Da) 27131
Sequence Human SMAC protein sequence
Species Mouse SMAC protein
Length 237
Mass (Da) 26820
Sequence Mouse SMAC protein sequence
Mass (Da)

SMAC Protein Molecular Weight & PI

Diablo homolog, mitochondrial precursor (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 56-239 Diablo homolog, mitochondrial.

Molecular weight (Da)


Theoretical pI


SMAC Protein Structure

Structure of the BIR domain of IAP-like protein 2
2004-08-27   Released:  2004-11-02
Deposition Author(s)
Shin, H., Renatus, M., Eckelman, B.P., Nunes, V.A., Sampaio, C.A.M., Salvesen, G.S.
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
2.2000 Å
R-Value Free
R-Value Work
1XB0 From PDB

Human SMAC protein Secondary structure

SMAC Protein Interaction

Recombinant SMAC Protein Feature

SMAC Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.
High Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant human SMAC-His (Cat:10339-H08E)at 10 μg/ml (100 μl/well) can bind recombinant human XIAP-AVI (Cat:10606-H17E) with a linear range of 0.125-1.0 μg/ml.

Bulk Order of Recombinant SMAC Protein

Please Leave Us a Message if you have any questions regarding bulk price quote of our products on the website, our customer specialist will get back to you in 24 hours by email.

Custom Recombinant SMAC Protein Service

Custom Recombinant Protein Production Service Features

  • Over 10 years' experience for 6000+ recombinant proteins production.
  • One-stop service from gene synthesis and vector construction to protein expression and purification.
  • Multiple protein expression systems: bacterial, yeast, baculovirus-insect and mammalian expression system.
  • Multiple purification systems (30+) to choose.
  • High R & D ability with over 1000 new proteins per year and quick problem-solving ability.
  • Close to 100 bioreactors with various volume between 2-1000 L to guarantee high-throughput and large-scale production.

Custom Recombinant Protein Production Service Advantages

  • High-efficiency expression vectors
  • High cell density culturing
  • Proprietary medium formulation
  • >6000 proteins expression and purification experience
  • High-efficiency expression vectors
  • High cell density culturing

Recombinant Protein Production Service Description

We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.