SMAC Information: SMAC Protein, SMAC Antibody and SMAC Gene

SMAC Gene family

SMAC Protein

SMAC protein function

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:14523016, ECO:0000269|PubMed:15200957}.

SMAC protein expression

Tissue specificity

Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.

SMAC protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

SMAC Antibody

There are 8 SMAC antibodies which are validated in multiple tissues with various applications, including WB, ELISA, ICC/IF, IP, FCM. There are 5 SMAC antibody for WB, 5 SMAC antibody for ELISA, 2 SMAC antibody for ICC/IF, 2 SMAC antibody for IP, 1 SMAC antibody for FCM. Among all these SMAC antibodies, there are 2 anti-SMAC mouse monoclonal antibodies , 3 anti-SMAC rabbit monoclonal antibodies , 3 anti-SMAC rabbit polyclonal antibodies . All the SMAC anbodies are produced in house and all are in stock. SMAC antibody customerized service is available.


DIABLO gene / cDNA is a protein-coding gene which located on 12q24.31. The DIABLO gene is conserved in chimpanzee, dog, cow, mouse, chicken, and frog.213 organisms have orthologs with human gene DIABLO.