ROCK1 Gene Sequence, Family, Fuction and Expression Information
ROCK1 cDNA / Gene Overview
Rock1 gene / cDNA is a protein-coding gene which located on 18q11.1. The ROCK1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.224 organisms have orthologs with human gene ROCK1.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
ROCK1 cDNA / Gene Sequence
LOCUS NM_005406 6650 bp mRNA linear PRI 29-JUL-2018
Homo sapiens Rho associated coiled-coil containing protein kinase 1 (ROCK1), mRNA.
NM_005406 XM_001713904 XM_001722015 XM_001723570
This sequence information is just for reference only.
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