ROCK1 Gene Sequence, Family, Fuction and Expression Information

ROCK1 cDNA / Gene Overview

Rock1 gene / cDNA is a protein-coding gene which located on 18q11.1. The ROCK1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.224 organisms have orthologs with human gene ROCK1.

ROCK1 cDNA / Gene Function

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]

ROCK1 cDNA / Gene Sequence

LOCUS
LOCUS NM_005406 6650 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens Rho associated coiled-coil containing protein kinase 1 (ROCK1), mRNA.
ACCESSION
NM_005406 XM_001713904 XM_001722015 XM_001723570
VERSION
NM_005406.2

This sequence information is just for reference only.

ROCK1 Family & Reagents

ROCK1 Gene family reagents (Pleckstrin homology domain containing)

Approved Symbol Reagent list
GRK2
AKT2
BTK
ITK
PRKD2
Approved Symbol Reagent list
AKT1
AKT3
COL4A3BP
PLEK
PRKD3

ROCK1 Gene family reagents (AGC family kinases)

Approved Symbol Reagent list
GRK2
AKT2
CDC42BPB
GRK6
PRKCI
RPS6KA6
Approved Symbol Reagent list
AKT1
AKT3
GRK5
PRKCD
RPS6KA2
RPS6KB1

ROCK1 cDNA / Gene Alias

  • p160ROCK

ROCK1 cDNA / Gene Expression

Ubiquitous expression in bone marrow (RPKM 22.1), fat (RPKM 16.6) and 25 other tissues

Recombinant ROCK1 protein citations

Title
Substrate Stiffness Modulates Renal Progenitor Cell Properties via a ROCK-Mediated Mechanotransduction Mechanism
Year
2019
Author
Melica, ME;La Regina, G;Parri, M;Peired, AJ;Romagnani, P;Lasagni, L;
Journal
Cells
Title
TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor
Year
2019
Author
Wang, L;Chang, X;Feng, J;Yu, J;Chen, G;
Journal
Front Cell Dev Biol