ROCK1 Information: ROCK1 Protein, ROCK1 Antibody and ROCK1 Gene

ROCK1 Gene family

ROCK1 Protein

ROCK1 protein function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}.

ROCK1 protein expression

Tissue specificity

Detected in blood platelets.

ROCK1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,354.00
  • Mass (KDa)
    158.00

ROCK1 Antibody

There are 3 ROCK1 antibodies which are validated in multiple tissues with various applications, including IP, IHC-P, ICC/IF. There are 1 ROCK1 antibody for IP, 1 ROCK1 antibody for IHC-P, 1 ROCK1 antibody for ICC/IF. Among all these ROCK1 antibodies, there are 3 anti-ROCK1 rabbit polyclonal antibodies . All the ROCK1 anbodies are produced in house and all are in stock. ROCK1 antibody customerized service is available.

ROCK1 Gene

Rock1 gene / cDNA is a protein-coding gene which located on 18q11.1. The ROCK1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.224 organisms have orthologs with human gene ROCK1.