Olig2 Gene Sequence, Family, Fuction and Expression Information

Olig2 cDNA / Gene Overview

OLIG2 gene / cDNA is a protein-coding gene which located on 21q22.11. The OLIG2 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog.156 organisms have orthologs with human gene OLIG2.

Olig2 cDNA / Gene Function

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

Olig2 cDNA / Gene Sequence

LOCUS
LOCUS NM_005806 2521 bp mRNA linear PRI 03-JUN-2018
DEFINITION
Homo sapiens oligodendrocyte transcription factor 2 (OLIG2), mRNA.
ACCESSION
NM_005806
VERSION
NM_005806.3

This sequence information is just for reference only.

Olig2 Family & Reagents

Olig2 Gene family reagents (Basic helix-loop-helix proteins)

Approved Symbol Reagent list
HIF1A
MITF
Approved Symbol Reagent list
MAX
   

Olig2 cDNA / Gene Alias

  • basic domain
  • helix-loop-helix protein
  • class B
  • 1
  • bHLHe19
  • human protein kinase C-binding protein RACK17
  • OLIGO2
  • oligodendrocyte-specific bHLH transcription factor 2
  • protein kinase C binding protein 2
  • RACK17

Olig2 cDNA / Gene Expression

Restricted expression toward brain (RPKM 29.0)