NRAS Gene Sequence, Family, Fuction and Expression Information
NRAS cDNA / Gene Overview
NRAS gene / cDNA is a protein-coding gene which located on 1p13.2. The NRAS gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.194 organisms have orthologs with human gene NRAS.
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
NRAS cDNA / Gene Sequence
LOCUS NM_002524 4454 bp mRNA linear PRI 29-JUL-2018
Homo sapiens NRAS proto-oncogene, GTPase (NRAS), mRNA.
This sequence information is just for reference only.
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