NRAS Gene Sequence, Family, Fuction and Expression Information

NRAS cDNA / Gene Overview

NRAS gene / cDNA is a protein-coding gene which located on 1p13.2. The NRAS gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.194 organisms have orthologs with human gene NRAS.

NRAS cDNA / Gene Function

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

NRAS cDNA / Gene Sequence

LOCUS
LOCUS NM_002524 4454 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens NRAS proto-oncogene, GTPase (NRAS), mRNA.
ACCESSION
NM_002524
VERSION
NM_002524.4

This sequence information is just for reference only.

NRAS Family & Reagents

NRAS Gene family reagents (RAS type GTPase family)

Approved Symbol Reagent list
DIRAS3
KRAS
Approved Symbol Reagent list
HRAS
RHEB

NRAS cDNA / Gene Alias

  • N-ras

NRAS cDNA / Gene Expression

Ubiquitous expression in bone marrow (RPKM 23.0), colon (RPKM 17.3) and 25 other tissues