Midkine Information: Midkine Protein, Midkine Antibody and Midkine Gene

Midkine Protein

Midkine protein function

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:1768439}.

Midkine protein expression

Tissue specificity

Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.

Induction

By heparin and retinoic acid.

Midkine protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    143.00
  • Mass (KDa)
    15.00

Midkine Antibody

There are 1 Midkine antibodies which are validated in multiple tissues with various applications, including ELISA. There are 1 Midkine antibody for ELISA. Among all these Midkine antibodies, there are 1 anti-Midkine mouse monoclonal antibodies . All the Midkine anbodies are produced in house and all are in stock. Midkine antibody customerized service is available.

Midkine Gene

MDK gene / cDNA is a protein-coding gene which located on 11p11.2. The MDK gene is conserved in Rhesus monkey, cow, mouse, rat, chicken, zebrafish, and frog.218 organisms have orthologs with human gene MDK.