KDM5B Gene Sequence, Family, Fuction and Expression Information

KDM5B cDNA / Gene Overview

KDM5B cDNA / gene is a gene with protein product which located on 1q32.1. The KDM5B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog. 210 organisms have orthologs with human gene KDM5B.

KDM5B cDNA / Gene Function

This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

KDM5B cDNA / Gene Sequence

LOCUS
AJ243706 7450 bp mRNA linear PRI 07-OCT-2008
DEFINITION
Homo sapiens mRNA for RB-binding protein (rbbp2h1a gene).
ACCESSION
AJ243706
VERSION
AJ243706.1

This sequence information is just for reference only.

KDM5B Family & Reagents

KDM5B Gene family reagents (PHD finger proteins)

Approved Symbol Reagent list
ING4
Approved Symbol Reagent list
ING5

KDM5B Gene family reagents (Lysine demethylases)

Approved Symbol Reagent list
KDM1A

KDM5B cDNA / Gene Alias

  • cancer / testis antigen 31
  • CT31
  • PLU-1
  • PPP1R98
  • protein phosphatase 1
  • regulatory subunit 98
  • RBBP2H1A

KDM5B cDNA / Gene Expression

Broad expression in testis (RPKM 55.0), skin (RPKM 8.8) and 18 other tissues