This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
IL21 cDNA / Gene Sequence
LOCUS NM_021803 3146 bp mRNA linear PRI 31-JUL-2018
Homo sapiens interleukin 21 (IL21), transcript variant 1, mRNA.
This sequence information is just for reference only.
Biased expression in lymph node (RPKM 3.2), testis (RPKM 0.8) and 2 other tissues
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