IL17 Protein Overview: Sequence, Structure, Function and Protein Interaction

IL17 Protein Overview

IL17 is a proinflammatory cytokine that is secreted primarily by activated T cells and that has been implicated in several important inflammatory human diseases. IL17 stimulates a variety of cells to produce inflammatory mediators including IL1 (see 147760), TNFA (191160), and chemokines. These events ultimately lead to the recruitment of neutrophils and other leukocytes that is the hallmark of inflammatory disease (summary by Lopez Kostka et al., 2009).

IL17 protein family

Belongs to the IL-17 family.

IL17 protein name

Recommended name
Interleukin-17A
Short name
IL-17||IL-17A||CTLA-8
Aliases
cytotoxic T-lymphocyte-associated protein 8, IL-17, IL-17A
Alternative name
Cytotoxic T-lymphocyte-associated antigen 8

IL17 Protein Sequence

Species Human IL17 protein
Length 155
Mass (Da) 17504
Sequence Human IL17 protein sequence
Species Mouse IL17 protein
Length 158
Mass (Da) 17490
Sequence Mouse IL17 protein sequence
Species Rat IL17 protein
Length 150
Mass (Da) 16877
Sequence Rat IL17 protein sequence

IL17 Protein Molecular Weight & PI

Interleukin-17A precursor (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 24-155 Interleukin-17A.

Molecular weight (Da)

15124.1

Theoretical pI

8.62

IL17 Protein Structure

Structure of IL-17A in complex with a potent, fully human neutralising antibody
Deposited
2008-07-09   Released:  2009-07-14
Deposition Author(s)
Gerhardt, S., Hargreaves, D., Pauptit, R.A., Davies, R.A., Russell, C., Welsh, F., Tuske, S.J., Coales, S.J., Hamuro, Y., Needham, M.R.C., Langham, C., Barker, W., Bell, P., Aziz, A., Smith, M.J., Dawson, S., Abbott, W.M.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.6300 Å
R-Value Free
0.264
R-Value Work
0.213
2VXS From PDB

Human IL17 protein Secondary structure

IL17 Protein Interaction

Recombinant IL17 Protein Feature

IL17 Protein, Human, Recombinant

High Purity
> 85 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its binding ability in a functional ELISA. Immobilized human IL17A (cat:12047-HNAS) at 10 μg/ml (100 μl/well) can bind human IL17Ra (Cat:10895-H03H), The EC50 of human IL17Ra (Cat:10895-H03H) is 20.0-48.0 ng/ml. 2. Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells in the presense of 20ng/mL TNFα. The ED50for this effect is 0.2-1ng/mL.

Recombinant IL17 protein citations

Title
Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling
Year
2016
Author
Zhang, H;Ju, B;Zhang, X;Zhu, Y;Nie, Y;Xu, Y;Lei, Q;
Journal
Basic & Clinical Phamacology & Toxocology
Title
Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model
Year
2016
Author
Deng, Q;Chen, H;Liu, Y;Xiao, F;Guo, L;Liu, D;Cheng, X;Zhao, M;Wang, X;Xie, S;Qi, S;Yin, Z;Gao, J;Chen, X;Wang, J;Guo, N;Ma, Y;Shi, M;
Journal
Brain Behav. Immun.
Title
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis
Year
2017
Author
Lei, H;Li, X;Jing, B;Xu, H;Wu, Y;
Journal
PLoS ONE
Title
Computational Design of Epitope-Specific Functional Antibodies
Year
2018
Author
Nimrod, G;Fischman, S;Austin, M;Herman, A;Keyes, F;Leiderman, O;Hargreaves, D;Strajbl, M;Breed, J;Klompus, S;Minton, K;Spooner, J;Buchanan, A;Vaughan, TJ;Ofran, Y;
Journal
Cell Rep
Title
The effects of interleukin 17A on left stellate ganglion remodeling are mediated by neuroimmune communication in normal structural hearts
Year
2019
Author
Deng, J;Zhou, X;Wang, M;Wang, M;Zhou, L;Meng, G;Wang, Y;Wang, Z;Zhang, Y;Zhou, Z;Yu, L;Jiang, H;
Journal
Int. J. Cardiol.
Title
Improvement in affinity and thermostability of a fully human antibody against interleukin-17A by yeast-display technology and CDR grafting
Year
2019
Author
Sun, W;Yang, Z;Lin, H;Liu, M;Zhao, C;Hou, X;Hu, Z;Cui, B;
Journal
Acta Pharmaceutica Sinica B

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