IL-29 Protein Overview: Sequence, Structure, Function and Protein Interaction

IL-29 Protein Overview

IL29, or IFNL1, belongs to the interferon-lambda family (also known as type III interferons), whose members are distantly related to both type I interferons (e.g., IFNA2; 147562) and members of the IL10 (124092) family. IL29 has significant antiviral activity and immunoregulatory properties and appears to inhibit T helper-2 (Th2) responses (Srinivas et al., 2008).

IL-29 protein family

Belongs to the lambda interferon family.

IL-29 protein name

Recommended name
Interferon lambda-1
Short name
Alternative name
Cytokine Zcyto21 Interleukin-29

IL-29 Protein Sequence

Species Human IL-29 protein
Length 200
Mass (Da) 21898
Sequence Human IL-29 protein sequence
Mass (Da)
Mass (Da)

IL-29 Protein Molecular Weight & PI

Interferon lambda-1 precursor (IFN-lambda-1) (Cytokine Zcyto21) (Interleukin-29) (IL-29) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 20-200 Interferon lambda-1.

Molecular weight (Da)


Theoretical pI


IL-29 Protein Structure

The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P212121
2010-08-16   Released:  2010-10-20
Deposition Author(s)
Miknis, Z.J., Magracheva, E., Lei, W., Zdanov, A., Kotenko, S.V., Wlodawer, A.
Homo sapiens
Expression System
Drosophila melanogaster
Experimental Data Snapshot
2.0970 Å
R-Value Free
R-Value Work
3OG6 From PDB

Human IL-29 protein Secondary structure

IL-29 Protein Interaction

Recombinant IL-29 Protein Feature

IL-29 Protein, Human, Recombinant (His Tag)

High Purity
> 92 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured in antiviral assays using HepG2 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is typically 4-20 ng/ml.

Recombinant IL-29 protein citations

Tanapoxvirus lacking the 15L gene inhibits melanoma cell growth in vitro by inducing interferon-λ1 release
Zhang, T;Essani, K;
Virus Genes

Bulk Order of Recombinant IL-29 Protein

Please Leave Us a Message if you have any questions regarding bulk price quote of our products on the website, our customer specialist will get back to you in 24 hours by email.

Custom Recombinant IL-29 Protein Service

Custom Recombinant Protein Production Service Features

  • Over 10 years' experience for 6000+ recombinant proteins production.
  • One-stop service from gene synthesis and vector construction to protein expression and purification.
  • Multiple protein expression systems: bacterial, yeast, baculovirus-insect and mammalian expression system.
  • Multiple purification systems (30+) to choose.
  • High R & D ability with over 1000 new proteins per year and quick problem-solving ability.
  • Close to 100 bioreactors with various volume between 2-1000 L to guarantee high-throughput and large-scale production.

Custom Recombinant Protein Production Service Advantages

  • High-efficiency expression vectors
  • High cell density culturing
  • Proprietary medium formulation
  • >6000 proteins expression and purification experience
  • High-efficiency expression vectors
  • High cell density culturing

Recombinant Protein Production Service Description

We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.