IFN-beta Gene Sequence, Family, Fuction and Expression Information

IFN-beta cDNA / Gene Overview

IFNB1 gene / cDNA is a protein-coding gene which located on 9p21.3. The IFNB1 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, and rat.97 organisms have orthologs with human gene IFNB1.

IFN-beta cDNA / Gene Function

This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]

IFN-beta cDNA / Gene Sequence

LOCUS
LOCUS NM_002176 859 bp mRNA linear PRI 15-JUL-2018
DEFINITION
Homo sapiens interferon beta 1 (IFNB1), mRNA.
ACCESSION
NM_002176
VERSION
NM_002176.3

This sequence information is just for reference only.

IFN-beta Family & Reagents

Gene family

IFN-beta Gene family reagents (Interferons)

Approved Symbol Reagent list
IFNA1
IFNA13
IFNA2
IFNA5
IFNA8
IFNL1
IFNL3
IL6
Approved Symbol Reagent list
IFNA10
IFNA14
IFNA4
IFNA7
IFNG
IFNL2
IFNW1
   

IFN-beta cDNA / Gene Alias

  • IFB
  • IFF