FGFR3 Gene Sequence, Family, Fuction and Expression Information

FGFR3 cDNA / Gene Overview

FGFR3 gene / cDNA is a protein-coding gene which located on 4p16.3. The FGFR3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, and frog.211 organisms have orthologs with human gene FGFR3.

FGFR3 cDNA / Gene Function

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]

FGFR3 cDNA / Gene Sequence

LOCUS
LOCUS NM_000142 4304 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, mRNA.
ACCESSION
NM_000142
VERSION
NM_000142.4

This sequence information is just for reference only.

FGFR3 Family & Reagents

FGFR3 Gene family reagents (Receptor Tyrosine Kinases)

Approved Symbol Reagent list
MUSK
AXL
DDR1
FGFR1
PDGFRA
DDR2
MERTK
FLT4
ROR1
TEK
Approved Symbol Reagent list
MET
INSR
Tie1
IGF1R
RYK
KDR
PTK7
NTRK1
MST1R
CSF1R

FGFR3 Gene family reagents (CD molecules)

Approved Symbol Reagent list
LILRB3
CD34
TNFSF14
SIRPG
ENPEP
CD24
BTN3A1
CD302
ENPP3
ADAM17
Approved Symbol Reagent list
SPN
F3
LAIR2
CD160
CD4
TNFSF13B
PDGFRB
CR2
PROCR
TNFRSF10D

FGFR3 Gene family reagents (I-set domain containing)

Approved Symbol Reagent list
NECTIN3
NTM
FGFR4
ADAMTSL1
CADM2
KIRREL2
CEACAM5
NPTN
NTRK3
IGFBP7
Approved Symbol Reagent list
FLT1
KIRREL3
MUSK
CNTN5
NFASC
LRIG1
TMIGD1
CNTN4
MDGA2
MFAP3

FGFR3 cDNA / Gene Alias

  • CD333
  • CEK2
  • JTK4

FGFR3 cDNA / Gene Expression

Biased expression in skin (RPKM 120.7), esophagus (RPKM 18.0) and 8 other tissues