FGFR3 Information: FGFR3 Protein, FGFR3 Antibody and FGFR3 Gene

FGFR3 Gene family

FGFR3 Protein

FGFR3 protein function

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}.

FGFR3 protein expression

Tissue specificity

Expressed in brain, kidney and testis. Very low or no expression in spleen, heart, and muscle. In 20- to 22-week old fetuses it is expressed at high level in kidney, lung, small intestine and brain, and to a lower degree in spleen, liver, and muscle. Isoform 2 is detected in epithelial cells. Isoform 1 is not detected in epithelial cells. Isoform 1 and isoform 2 are detected in fibroblastic cells.

FGFR3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

FGFR3 Antibody

There are 9 FGFR3 antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA, ELISA(Cap), ELISA(Det). There are 3 FGFR3 antibody for IHC-P, 6 FGFR3 antibody for ELISA, 1 FGFR3 antibody for ELISA(Cap), 1 FGFR3 antibody for ELISA(Det). Among all these FGFR3 antibodies, there are 1 anti-FGFR3 mouse monoclonal antibodies , 6 anti-FGFR3 rabbit polyclonal antibodies , 2 anti-FGFR3 rabbit monoclonal antibodies . All the FGFR3 anbodies are produced in house and all are in stock. FGFR3 antibody customerized service is available.

FGFR3 Gene

FGFR3 gene / cDNA is a protein-coding gene which located on 4p16.3. The FGFR3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, and frog.211 organisms have orthologs with human gene FGFR3.