ERK5/BMK1/MAPK7 Protein Overview: Sequence, Structure, Function and Protein Interaction

ERK5/BMK1/MAPK7 Protein Overview

Mitogen-activated protein kinases (MAPKs, or PRKMs) are activated by an upstream cascade of kinases in response to a wide variety of extracellular stimuli. Specific PRKM kinases (MAPKKs, or PRKMKs) have been shown to phosphorylate and activate specific PRKMs in a given signaling pathway. Using the yeast 2-hybrid system with mutant forms of PRKMK5 (602520) as baits, Zhou et al. (1995) identified a cDNA encoding MAPK7, called ERK5 by them. They demonstrated that MAPK7 interacts specifically with PRKMK5, but not with PRKMK1 (176872) or PRKMK2 (601263), suggesting that the PRKMK5/MAPK7 protein cascade is a novel signaling pathway. The 815-amino acid MAPK7 contains the conserved thr-glu-tyr activation motif of ERK-type MAPKs. MAPK7 has an uncharacteristic 400-amino acid C-terminal domain with sequences indicating that it may be targeted to the cytoskeleton. Zhou et al. (1995) found that full-length MAPK7 has no detectable kinase activity in vitro, whereas removal of the C terminus results in autophosphorylation, suggesting that the C terminus may play a role in regulating MAPK7. Northern blot analysis detected a 3.1-kb transcript in a number of human tissues, with the highest levels in heart and skeletal muscle. By degenerate PCR, Lee et al. (1995) isolated a cDNA encoding a PRKM which they named BMK1. BMK1 shows 98% amino acid identity to ERK5; they differ in a short span of residues at the N terminus. Lee et al. (1995) speculated that these kinases are derived from the same gene, possibly via differential mRNA splicing.

ERK5/BMK1/MAPK7 protein family

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

ERK5/BMK1/MAPK7 protein name

Recommended name
Mitogen-activated protein kinase 7
BMK1, BMK1 kinase, ERK5, extracellular-signal-regulated kinase 5

ERK5/BMK1/MAPK7 Gene family protein

ERK5/BMK1/MAPK7 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 2-816 Mitogen-activated protein kinase 7.

Molecular weight (Da)


Theoretical pI


Bulk Order of Recombinant ERK5/BMK1/MAPK7 Protein

Please Leave Us a Message if you have any questions regarding bulk price quote of our products on the website, our customer specialist will get back to you in 24 hours by email.

Custom Recombinant ERK5/BMK1/MAPK7 Protein Service

Custom Recombinant Protein Production Service Features

  • Over 10 years' experience for 6000+ recombinant proteins production.
  • One-stop service from gene synthesis and vector construction to protein expression and purification.
  • Multiple protein expression systems: bacterial, yeast, baculovirus-insect and mammalian expression system.
  • Multiple purification systems (30+) to choose.
  • High R & D ability with over 1000 new proteins per year and quick problem-solving ability.
  • Close to 100 bioreactors with various volume between 2-1000 L to guarantee high-throughput and large-scale production.

Custom Recombinant Protein Production Service Advantages

  • High-efficiency expression vectors
  • High cell density culturing
  • Proprietary medium formulation
  • >6000 proteins expression and purification experience
  • High-efficiency expression vectors
  • High cell density culturing

Recombinant Protein Production Service Description

We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.