ERK5/BMK1/MAPK7 Gene Sequence, Family, Fuction and Expression Information

ERK5/BMK1/MAPK7 cDNA / Gene Overview

MAPK7 cDNA / gene is a gene with protein product which located on 17p11.2. The MAPK7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. 174 organisms have orthologs with human gene MAPK7.

ERK5/BMK1/MAPK7 cDNA / Gene Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

ERK5/BMK1/MAPK7 cDNA / Gene Sequence

LOCUS
HSU25278 2828 bp mRNA linear PRI 16-NOV-1995
DEFINITION
Human ERK5 mRNA, complete cds.
ACCESSION
U25278
VERSION
U25278.1

This sequence information is just for reference only.

ERK5/BMK1/MAPK7 Family & Reagents

ERK5/BMK1/MAPK7 Gene family reagents (Mitogen-activated protein kinases)

Approved Symbol Reagent list
MAPK1
MAPK13
MAPK8
Approved Symbol Reagent list
MAPK12
MAPK14
MAPK9

ERK5/BMK1/MAPK7 cDNA / Gene Alias

  • BMK1
  • BMK1 kinase
  • ERK5
  • extracellular-signal-regulated kinase 5

ERK5/BMK1/MAPK7 cDNA / Gene Expression

Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues