ERK5/BMK1/MAPK7 Information: ERK5/BMK1/MAPK7 Protein, ERK5/BMK1/MAPK7 Antibody and ERK5/BMK1/MAPK7 Gene

ERK5/BMK1/MAPK7 Gene family

ERK5/BMK1/MAPK7 Protein

ERK5/BMK1/MAPK7 protein function

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

ERK5/BMK1/MAPK7 protein expression

Tissue specificity

Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.

ERK5/BMK1/MAPK7 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    816.00
  • Mass (KDa)
    88.00

ERK5/BMK1/MAPK7 Gene

MAPK7 cDNA / gene is a gene with protein product which located on 17p11.2. The MAPK7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. 174 organisms have orthologs with human gene MAPK7.