EGFR Gene Sequence, Family, Fuction and Expression Information

EGFR cDNA / Gene Overview

EGFR gene / cDNA is a protein-coding gene which located on 7p11.2. The EGFR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.216 organisms have orthologs with human gene EGFR.

EGFR cDNA / Gene Function

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]

EGFR cDNA / Gene Sequence

LOCUS
LOCUS NM_005228 6369 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.
ACCESSION
NM_005228
VERSION
NM_005228.4

This sequence information is just for reference only.

EGFR Family & Reagents

EGFR Gene family reagents (Erb-b2 receptor tyrosine kinases)

Approved Symbol Reagent list
ERBB2
ERBB4
Approved Symbol Reagent list
ERBB3
   

EGFR cDNA / Gene Alias

  • ERBB1
  • erb-b2 receptor tyrosine kinase 1
  • erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)

EGFR cDNA / Gene Expression

Broad expression in placenta (RPKM 36.6), skin (RPKM 15.6) and 22 other tissues

Recombinant EGFR protein citations

Title
Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR
Year
2014
Author
Yao, S;Zheng, P;Wu, H;Song, LM;Ying, XF;Xing, C;Li, Y;Xiao, ZQ;Zhou, XN;Shen, T;Chen, L;Liu, YH;Lai, M;Mei, L;Gao, TM;Li, JM;
Journal
J. Pathol.
Title
Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR
Year
2014
Author
Yao, S;Zheng, P;Wu, H;Song, LM;Ying, XF;Xing, C;Li, Y;Xiao, ZQ;Zhou, XN;Shen, T;Chen, L;Liu, YH;Lai, M;Mei, L;Gao, TM;Li, JM;
Journal
J. Pathol.
Title
Immunoselective Cellulose Nanospheres: A Versatile Platform for Nanotheranostics
Year
2014
Author
C Carrick, L Wågberg, PA Larsson
Journal
ACS Macro Letters
Title
In vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cells
Year
2014
Author
Niesen, J;Brehm, H;Stein, C;Berges, N;Pardo, A;Fischer, R;Ten Haaf, A;Gattenlöhner, S;Tur, MK;Barth, S;
Journal
J. Cancer Res. Clin. Oncol.
Title
The correlation between the expression of drug resistance gene and the recurrence of osteosarcoma
Year
2014
Author
WANG, J;LU, H;SUN, Y;YAO, Y;
Journal
TUMOR
Title
Enhancing tumor-specific intracellular delivering efficiency of cell-penetrating peptide by fusion with a peptide targeting to EGFR
Year
2015
Author
Nguyen, LT;Yang, XZ;Du, X;Wang, JW;Zhang, R;Zhao, J;Wang, FJ;Dong, Y;Li, PF;
Journal
Amino Acids
Title
Tuning the surface chemistry of gold nanoparticles to specifically image glioblastoma cells using surface-enhanced Raman spectroscopy
Year
2020
Author
Burgio, F;Piffaretti, D;Schmidt, F;Pieles, U;Reinert, M;Ritz, M;Saxer, S;
Journal
ACS Appl. Nano Mater.
Title
Live circulating tumour cells selection on digitized self-assembled cell array (Digi-saca) chip by in-parallel/in-situ image analysis, cell capture, and cultivation
Year
2020
Author
Goudar, V;Yeh, P;Wu, S;Chu, C;Lu, L;Yang, C;Chiou, T;Tseng, F;
Journal
Sensors and Actuators B: Chemical
Title
In Situ-Generated Multivalent Aptamer Network for Efficient Capture and Sensitive Electrochemical Detection of Circulating Tumor Cells in Whole Blood
Year
2020
Author
Yang, J;Li, X;Jiang, B;Yuan, R;Xiang, Y;
Journal
Anal. Chem.
Title
Increasing the antitumor efficacy of doxorubicin liposomes with coupling an anti-EGFR affibody in EGFR-expressing tumor models
Year
2020
Author
Jia, D;Yang, Y;Yuan, F;Fan, Q;Wang, F;Huang, Y;Song, H;Hu, P;Wang, R;Li, G;Liu, R;Li, J;
Journal
Int J Pharm
Title
Reusable on-plate immunoprecipitation method with covalently immobilized antibodies on a protein G covered microtiter plate
Year
2020
Author
Korodi, M;Rákosi, K;Baibarac, M;Fejer, SN;
Journal
J. Immunol. Methods
Title
Reusable on-plate immunoprecipitation method with covalently immobilized antibodies on a protein G covered microtiter plate
Year
2020
Author
Korodi, M;Rákosi, K;Baibarac, M;Fejer, SN;
Journal
J. Immunol. Methods