EGFR Gene Sequence, Family, Fuction and Expression Information
EGFR cDNA / Gene Overview
EGFR gene / cDNA is a protein-coding gene which located on 7p11.2. The EGFR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.216 organisms have orthologs with human gene EGFR.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
EGFR cDNA / Gene Sequence
LOCUS NM_005228 6369 bp mRNA linear PRI 12-AUG-2018
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