DR4/TRAIL R1 Gene Sequence, Family, Fuction and Expression Information

DR4/TRAIL R1 cDNA / Gene Overview

TNFRSF10A gene / cDNA is a protein-coding gene which located on 8p21.3. The TNFRSF10A gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat.31 organisms have orthologs with human gene TNFRSF10A.

DR4/TRAIL R1 cDNA / Gene Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

DR4/TRAIL R1 cDNA / Gene Sequence

LOCUS
LOCUS NM_003844 1764 bp mRNA linear PRI 15-JUL-2018
DEFINITION
Homo sapiens TNF receptor superfamily member 10a (TNFRSF10A), mRNA.
ACCESSION
NM_003844
VERSION
NM_003844.3

This sequence information is just for reference only.

DR4/TRAIL R1 Family & Reagents

DR4/TRAIL R1 Gene family reagents (CD molecules)

Approved Symbol Reagent list
LY75
CEACAM6
PROCR
NCR3
CR2
NCR2
CD46
TNFSF14
TNFSF13
CD48
Approved Symbol Reagent list
CD180
BST2
FCGR3B
ENTPD1
CD28
CLEC12A
CD59
NECTIN1
CD164
TNFRSF14

DR4/TRAIL R1 Gene family reagents (Tumor necrosis factor receptor superfamily)

Approved Symbol Reagent list
TNFRSF1A
TNFRSF18
TNFRSF19
TNFRSF10B
TNFRSF14
TNFRSF13C
TNFRSF8
TNFRSF17
TNFRSF11B
EDAR
Approved Symbol Reagent list
TNFRSF12A
TNFRSF6B
TNFRSF10D
TNFRSF13B
TNFRSF10C
CD40
EDA2R
TNFRSF11A
TNFRSF9
LTBR

DR4/TRAIL R1 cDNA / Gene Alias

  • Apo2
  • CD261
  • DR4
  • TRAILR1
  • TRAILR-1

DR4/TRAIL R1 cDNA / Gene Expression

Ubiquitous expression in lymph node (RPKM 4.9), appendix (RPKM 4.2) and 24 other tissues

Recombinant DR4/TRAIL R1 protein citations

Title
A Novel Fully Human Agonistic Single Chain Fragment Variable Antibody Targeting Death Receptor 5 with Potent Antitumor Activity In Vitro and In Vivo
Year
2017
Author
Lei, G;Xu, M;Xu, Z;Gu, L;Lu, C;Bai, Z;Wang, Y;Zhang, Y;Hu, H;Jiang, Y;Zhao, W;Tan, S;
Journal
Int J Mol Sci