DR4/TRAIL R1 Information: DR4/TRAIL R1 Protein, DR4/TRAIL R1 Antibody and DR4/TRAIL R1 Gene

DR4/TRAIL R1 Gene family

DR4/TRAIL R1 Protein

DR4/TRAIL R1 protein function

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. {ECO:0000269|PubMed:26457518, ECO:0000269|PubMed:9430227}.

DR4/TRAIL R1 protein expression

Tissue specificity

Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

DR4/TRAIL R1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    468.00
  • Mass (KDa)
    50.00

DR4/TRAIL R1 Antibody

There are 10 DR4/TRAIL R1 antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), FCM, ELISA, ELISA(Det). There are 1 DR4/TRAIL R1 antibody for ELISA(Cap), 4 DR4/TRAIL R1 antibody for FCM, 6 DR4/TRAIL R1 antibody for ELISA, 1 DR4/TRAIL R1 antibody for ELISA(Det). Among all these DR4/TRAIL R1 antibodies, there are 4 anti-DR4/TRAIL R1 mouse monoclonal antibodies , 3 anti-DR4/TRAIL R1 rabbit monoclonal antibodies , 3 anti-DR4/TRAIL R1 rabbit polyclonal antibodies . All the DR4/TRAIL R1 anbodies are produced in house and all are in stock. DR4/TRAIL R1 antibody customerized service is available.

DR4/TRAIL R1 Gene

TNFRSF10A gene / cDNA is a protein-coding gene which located on 8p21.3. The TNFRSF10A gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat.31 organisms have orthologs with human gene TNFRSF10A.