Growth Factors & Receptors in Clinical use

Growth factors play an important role in various cellular processes. The growth factors themselves and their inhibitors or antibodies can be widely used in disease therapy. Nowadays, researchers have made great progress in the treatment of oncologic diseases, cardiovascular diseases, and diabetic mellitus etc. For example, a Her2 antibody named as Herceptin is designed to cure the breast cancer in women, whereas the Iresa, a tyrosine kinase inhibitor aimed at EGFR, shows the potential to prevent colon cancer and Non-small cell lung carcinoma. Hepatocyte growth factor can enhance the ability of cardiac stem cells to promote myocardial regeneration. Insulin-like growth factor-1 can be used for the treatment of diabetes mellitus, and epidermal growth factor has the potential to alleviate diabetic foot ulcers.

References

Patel DK. (2008) Clinical use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer. Pharmacotherapy. 28(11 Pt 2):31S-41S.
Li G, et al. (2010) The epidermal growth factor variant III peptide vaccine for treatment of malignant gliomas. Neurosurg Clin N Am. 21(1):87-93.
Pardali E, et al. (2009) Transforming growth factor-beta signaling and tumor angiogenesis. Front Biosci. 14:4848-61.