The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]
CXCL7 cDNA / Gene Sequence
LOCUS NM_002704 1307 bp mRNA linear PRI 05-AUG-2018
Homo sapiens pro-platelet basic protein (PPBP), mRNA.
This sequence information is just for reference only.
Biased expression in bone marrow (RPKM 35.8), spleen (RPKM 5.3) and 2 other tissues
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