CXCL7 Gene Sequence, Family, Fuction and Expression Information

CXCL7 cDNA / Gene Overview

PPBP gene / cDNA is a protein-coding gene which located on 4q13.3. 66 organisms have orthologs with human gene PPBP.

CXCL7 cDNA / Gene Function

The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]

CXCL7 cDNA / Gene Sequence

LOCUS
LOCUS NM_002704 1307 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens pro-platelet basic protein (PPBP), mRNA.
ACCESSION
NM_002704
VERSION
NM_002704.3

This sequence information is just for reference only.

CXCL7 Family & Reagents

Gene family

CXCL7 Gene family reagents (Endogenous ligands)

Approved Symbol Reagent list
FN1
Fgf8
LGALS3
MLN
Spp1
GHRH
THPO
FGF7
RSPO3
AGT
Approved Symbol Reagent list
BID
IL1A
NTS
GIP
CCL22
C3
VCAM1
FASLG
RSPO1
CX3CL1

CXCL7 cDNA / Gene Alias

  • Beta-TG
  • beta-thromboglobulin
  • b-TG1
  • chemokine (C-X-C motif) ligand 7
  • connective tissue-activating peptide III
  • CTAP3
  • CTAPIII
  • CXCL7
  • LA-PF4
  • LDGF
  • MDGF
  • NAP-2
  • NAP-2-L1
  • neutrophil-activating peptide-2
  • PBP
  • platelet basic protein
  • SCYB7
  • TGB
  • TGB1

CXCL7 cDNA / Gene Expression

Biased expression in bone marrow (RPKM 35.8), spleen (RPKM 5.3) and 2 other tissues