CIDEA Protein Overview: Sequence, Structure, Function and Protein Interaction

CIDEA Protein Overview

DFF45 (601882) is a subunit of the DNA fragmentation factor (DFF) that is cleaved by caspase-3 (600636) during apoptosis. Inohara et al. (1998) identified 2 mammalian genes, CIDEA and CIDEB (604441), encoding highly related proteins with homology to the N-terminal region of DFF45. Wang et al. (2012) found that Cidea was highly expressed in epithelia, but not surrounding adipose tissue, in lactating mouse mammary glands. Cidea expression was low in mammary glands prior to pregnancy and during postlactational involution. Cidea was also expressed in isolated lactating mammary epithelial cells and isolated milk fat globules. A substantial portion of Cidea was detected in the nuclear fraction of lactating mammary glands and brown adipose tissue.

CIDEA protein name

Recommended name
Cell death activator CIDE-A
Alternative name
Cell death-inducing DFFA-like effector A

CIDEA Protein Sequence

Species Human CIDEA protein
Length 219
Mass (Da) 24687
Sequence Human CIDEA protein sequence
Species Mouse CIDEA protein
Length 217
Mass (Da) 24669
Sequence Mouse CIDEA protein sequence
Mass (Da)

CIDEA Protein Molecular Weight & PI

Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-219 Cell death activator CIDE-A.

Molecular weight (Da)


Theoretical pI


CIDEA Protein Structure

Solution structure of the CIDE-N domain of human cell death activator CIDE-A
2007-02-15   Released:  2007-08-21
Deposition Author(s)
Qin, X.R., Nagashima, T., Hayashi, F., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Homo sapiens
Experimental Data Snapshot

Human CIDEA protein Secondary structure

CIDEA Protein Interaction

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