CHOP/DDIT3 Information: CHOP/DDIT3 Protein, CHOP/DDIT3 Antibody and CHOP/DDIT3 Gene

CHOP/DDIT3 Protein

CHOP/DDIT3 protein function

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. {ECO:0000269|PubMed:15322075, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16434966, ECO:0000269|PubMed:17709599, ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:19672300, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:20876114, ECO:0000269|PubMed:22761832}.

CHOP/DDIT3 protein expression

Induction

By oxidative stress, amino-acid deprivation, hypoxia and ER stress. During ER stress, induced by a EIF2AK3/ATF4 pathway and/or ERN1/ATF6 pathway. Expression is suppressed by TLR-TRIF signaling pathway during prolonged ER stress.

CHOP/DDIT3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    169.00
  • Mass (KDa)
    19.00

CHOP/DDIT3 Antibody

There are 3 CHOP/DDIT3 antibodies which are validated in multiple tissues with various applications, including ICC/IF, IHC-P, WB. There are 2 CHOP/DDIT3 antibody for ICC/IF, 1 CHOP/DDIT3 antibody for IHC-P, 1 CHOP/DDIT3 antibody for WB. Among all these CHOP/DDIT3 antibodies, there are 3 anti-CHOP/DDIT3 rabbit polyclonal antibodies . All the CHOP/DDIT3 anbodies are produced in house and all are in stock. CHOP/DDIT3 antibody customerized service is available.

CHOP/DDIT3 Gene

DDIT3 gene / cDNA is a protein-coding gene which located on 12q13.3. The DDIT3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog.191 organisms have orthologs with human gene DDIT3.