CD89 Gene Sequence, Family, Fuction and Expression Information

CD89 cDNA / Gene Overview

FCAR gene / cDNA is a protein-coding gene which located on 19q13.42. The FCAR gene is conserved in chimpanzee, Rhesus monkey, cow, and rat.51 organisms have orthologs with human gene FCAR.

CD89 cDNA / Gene Function

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

CD89 cDNA / Gene Sequence

LOCUS
LOCUS NM_002000 2618 bp mRNA linear PRI 01-JUL-2018
DEFINITION
Homo sapiens Fc fragment of IgA receptor (FCAR), transcript variant 1, mRNA.
ACCESSION
NM_002000
VERSION
NM_002000.3

This sequence information is just for reference only.

CD89 Family & Reagents

CD89 Gene family reagents (CD molecules)

Approved Symbol Reagent list
VCAM1
JAG1
FCGR1A
CD19
PTPRJ
CSF3R
ENPP3
CD180
BSG
BTLA
Approved Symbol Reagent list
MPL
SIGLEC5
CD34
CD36
GP1BB
ADGRE5
SPN
CD53
PROM1
IL6ST

CD89 Gene family reagents (Immunoglobulin like domain containing)

Approved Symbol Reagent list
FCMR
FCRL1
ALCAM
CDON
CD160
PTK7
TEK
CNTFR
MUSK
IL1RAP
Approved Symbol Reagent list
CEACAM1
SLAMF8
VCAM1
IL11RA
CD244
CADM4
PDCD1LG2
ICAM2
CD48
IGSF3

CD89 cDNA / Gene Alias

  • CD89

CD89 cDNA / Gene Expression

Restricted expression toward bone marrow (RPKM 95.4)