CD3 epsilon/CD3e Gene Sequence, Family, Fuction and Expression Information
CD3 epsilon/CD3e cDNA / Gene Overview
CD3E gene / cDNA is a protein-coding gene which located on 11q23.3. The CD3E gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.228 organisms have orthologs with human gene CD3E.
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
CD3 epsilon/CD3e cDNA / Gene Sequence
LOCUS NM_000733 1534 bp mRNA linear PRI 24-JUN-2018
Homo sapiens CD3e molecule (CD3E), mRNA.
This sequence information is just for reference only.
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