CD3 epsilon/CD3e Gene Sequence, Family, Fuction and Expression Information

CD3 epsilon/CD3e cDNA / Gene Overview

CD3E gene / cDNA is a protein-coding gene which located on 11q23.3. The CD3E gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.228 organisms have orthologs with human gene CD3E.

CD3 epsilon/CD3e cDNA / Gene Function

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

CD3 epsilon/CD3e cDNA / Gene Sequence

LOCUS
LOCUS NM_000733 1534 bp mRNA linear PRI 24-JUN-2018
DEFINITION
Homo sapiens CD3e molecule (CD3E), mRNA.
ACCESSION
NM_000733
VERSION
NM_000733.3

This sequence information is just for reference only.

CD3 epsilon/CD3e Family & Reagents

Gene family

CD3 epsilon/CD3e Gene family reagents (CD molecules)

Approved Symbol Reagent list
IL6ST
CD164
FCER2
MME
BTLA
FCGR3B
CD300C
KDR
BST1
LILRB1
Approved Symbol Reagent list
IL18RAP
TREM1
CD86
CD7
CD207
IL10RA
SELL
SLAMF7
LILRA1
DDR1

CD3 epsilon/CD3e cDNA / Gene Expression

Biased expression in lymph node (RPKM 92.6), appendix (RPKM 45.9) and 9 other tissues

Recombinant CD3 epsilon/CD3e protein citations

Title
The role of Th1 / Th2 Cytokines played in Regulation of Specific CD4 + Th1 Cells Conversion and Activation during Inflammatory Reaction of Chronic Obstructive Pulmonary Disease
Year
2018
Author
Sun, J;Liu, T;Yan, Y;Huo, K;Zhang, W;Liu, H;Shi, Z;
Journal
Scand. J. Immunol.
Title
CD3E 蛋白真核表达及全人源 CD3 单克隆抗体的制备
Year
2020
Author
杨希, ;郎巧利, ;黄楠, ;余琳, ;吴梦, ;葛良鹏, ;
Journal
中国免疫学杂志