CD3 epsilon/CD3e Information: CD3 epsilon/CD3e Protein, CD3 epsilon/CD3e Antibody and CD3 epsilon/CD3e Gene

CD3 epsilon/CD3e Gene family

CD3 epsilon/CD3e Protein

CD3 epsilon/CD3e protein function

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). {ECO:0000269|PubMed:10384095, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15546002, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:26507128, ECO:0000269|PubMed:8490660}.

CD3 epsilon/CD3e protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    207.00
  • Mass (KDa)
    23.00

CD3 epsilon/CD3e Antibody

There are 19 CD3 epsilon/CD3e antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, FCM, Func/A, ELISA, IP. There are 4 CD3 epsilon/CD3e antibody for WB, 3 CD3 epsilon/CD3e antibody for IHC-P, 7 CD3 epsilon/CD3e antibody for FCM, 2 CD3 epsilon/CD3e antibody for Func/A, 6 CD3 epsilon/CD3e antibody for ELISA, 2 CD3 epsilon/CD3e antibody for IP. Among all these CD3 epsilon/CD3e antibodies, there are 4 anti-CD3 epsilon/CD3e rabbit polyclonal antibodies , 2 anti-CD3 epsilon/CD3e , 9 anti-CD3 epsilon/CD3e mouse monoclonal antibodies , 4 anti-CD3 epsilon/CD3e rabbit monoclonal antibodies . All the CD3 epsilon/CD3e anbodies are produced in house and all are in stock. CD3 epsilon/CD3e antibody customerized service is available.

CD3 epsilon/CD3e Gene

CD3E gene / cDNA is a protein-coding gene which located on 11q23.3. The CD3E gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.228 organisms have orthologs with human gene CD3E.