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CD20 Protein

CD20 Protein Overview

CD20 reagents

The MS4A1 gene encodes a member of the MS4A family of proteins that share structural similarity, amino acid sequence homology, and chromosomal location. MS4A proteins contain 4 highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions. MS4A1, also known as CD20 or B1, is a human B-lymphocyte surface molecule that is widely expressed during B-cell ontogeny, from early pre-B-cell developmental stages until final differentiation into plasma cells. Functional studies using monoclonal antibodies have shown that antibody binding to B1 inhibits B-cell proliferation caused by mitogens and inhibits B-cell differentiation. Tedder et al. (1988) described the primary structure of CD20.

CD20 protein family

Belongs to the MS4A family.

CD20 protein name

Recommended name
B-lymphocyte antigen CD20
B1, Bp35, MS4A2
Alternative name
B-lymphocyte surface antigen B1 Bp35 Leukocyte surface antigen Leu-16 Membrane-spanning 4-domains subfamily A member 1 CD_antigen: CD20

CD20 Protein Sequence

Species Human CD20 protein
Length 297
Mass (Da) 33077
Sequence Human CD20 protein sequence
Species Mouse CD20 protein
Length 291
Mass (Da) 31958
Sequence Mouse CD20 protein sequence
Mass (Da)

CD20 Protein Molecular Weight & PI

B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD20 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-297 B-lymphocyte antigen CD20.

Molecular weight (Da)


Theoretical pI


CD20 Protein Structure

Crystal structure of Rituximab Fab in complex with an epitope peptide
2007-02-06   Released:  2007-04-10
Deposition Author(s)
Du, J., Zhong, C., Ding, J.
Homo sapiens
Experimental Data Snapshot
2.6000 Å
R-Value Free
R-Value Work

Human CD20 protein Secondary structure

CD20 Protein Interaction

Recombinant CD20 Protein Feature

CD20 Protein, Human, Recombinant (TrxA Tag)

High Purity
> 80 % as determined by SDS-PAGE.
Low Endotoxin
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Custom Recombinant Protein Production Service Features

  • Over 10 years' experience for 6000+ recombinant proteins production.
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Custom Recombinant Protein Production Service Advantages

  • High-efficiency expression vectors
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  • High-efficiency expression vectors
  • High cell density culturing

Recombinant Protein Production Service Description

We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.