CASP8/ALPS2B Gene Sequence, Family, Fuction and Expression Information
CASP8/ALPS2B cDNA / Gene Overview
CASP8 cDNA / gene is a gene with protein product which located on 2q33.1. The CASP8 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 159 organisms have orthologs with human gene CASP8.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
CASP8/ALPS2B Gene family reagents (Death inducing signaling complex)
CASP8/ALPS2B cDNA / Gene Alias
CASP8/ALPS2B cDNA / Gene Expression
Broad expression in bone marrow (RPKM 26.3), lymph node (RPKM 15.2) and 21 other tissues
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