CaMKII beta/CAMK2B Information: CaMKII beta/CAMK2B Protein, CaMKII beta/CAMK2B Antibody and CaMKII beta/CAMK2B Gene

CaMKII beta/CAMK2B Gene family

CaMKII beta/CAMK2B Protein

CaMKII beta/CAMK2B protein function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. {ECO:0000269|PubMed:16690701}.

CaMKII beta/CAMK2B protein expression

Tissue specificity

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

Induction

Activity is induced in skeletal muscle during exercise.

CaMKII beta/CAMK2B protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    666.00
  • Mass (KDa)
    72.00

CaMKII beta/CAMK2B Antibody

There are 2 CaMKII beta/CAMK2B antibodies which are validated in multiple tissues with various applications, including WB, IHC-P. There are 1 CaMKII beta/CAMK2B antibody for WB, 1 CaMKII beta/CAMK2B antibody for IHC-P. Among all these CaMKII beta/CAMK2B antibodies, there are 2 anti-CaMKII beta/CAMK2B rabbit polyclonal antibodies . All the CaMKII beta/CAMK2B anbodies are produced in house and all are in stock. CaMKII beta/CAMK2B antibody customerized service is available.

CaMKII beta/CAMK2B Gene

CAMK2B gene / cDNA is a protein-coding gene which located on 7p13. The CAMK2B gene is conserved in cow, mouse, rat, chicken, zebrafish, and frog.176 organisms have orthologs with human gene CAMK2B.