CALML3 Protein Overview: Sequence, Structure, Function and Protein Interaction

CALML3 Protein Overview

Using calmodulin (CALM1; 114180) as probe, Koller and Strehler, (1988) cloned CALML3, which they designated GH6, from a leukocyte genomic library. The deduced 148-amino acid protein contains 4 helix-loop-helix Ca(2+)-binding motifs and shares 85% identity with vertebrate calmodulin. Northern blot analysis detected no expression in fibroblast, teratoma, or erythroleukemia cell lines. By immunohistochemical staining, Rogers et al. (2001) determined the tissue distribution of CALML3, which they designated CLP. CLP was expressed exclusively in the epithelium of the tissues surveyed and was most abundant in thyroid, breast, prostate, kidney, and skin. CLP expression appeared to increase in stratified epithelium during differentiation, as illustrated in skin, where CLP staining intensified from the basal through the spinous to the granular layers.

CALML3 protein family

Belongs to the calmodulin family.

CALML3 protein name

Recommended name
Calmodulin-like protein 3
Alternative name
CaM-like protein CLP Calmodulin-related protein NB-1

CALML3 Protein Sequence

Species Human CALML3 protein
Length 149
Mass (Da) 16891
Sequence Human CALML3 protein sequence
Species Mouse CALML3 protein
Length 149
Mass (Da) 16701
Sequence Mouse CALML3 protein sequence
Species Rat CALML3 protein
Length 149
Mass (Da) 16803
Sequence Rat CALML3 protein sequence

CALML3 Protein Molecular Weight & PI

Calmodulin-like protein 3 (CaM-like protein) (CLP) (Calmodulin-related protein NB-1) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-149 Calmodulin-like protein 3.

Molecular weight (Da)


Theoretical pI


CALML3 Protein Structure

2000-10-13   Released:  2002-06-05
Deposition Author(s)
Han, B.-G., Han, M., Sui, H., Yaswen, P., Walian, P.J., Jap, B.K.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
1.5000 Å
R-Value Free
R-Value Work

Human CALML3 protein Secondary structure

CALML3 Protein Interaction

Recombinant CALML3 Protein Feature

CALML3 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
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