BCAM Gene Sequence, Family, Fuction and Expression Information

BCAM cDNA / Gene Overview

BCAM gene / cDNA is a protein-coding gene which located on 19q13.32. The BCAM gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.138 organisms have orthologs with human gene BCAM.

BCAM cDNA / Gene Function

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

BCAM cDNA / Gene Sequence

LOCUS
LOCUS NM_005581 2470 bp mRNA linear PRI 25-JUN-2018
DEFINITION
Homo sapiens basal cell adhesion molecule (Lutheran blood group) (BCAM), transcript variant 1, mRNA.
ACCESSION
NM_005581
VERSION
NM_005581.4

This sequence information is just for reference only.

BCAM Family & Reagents

BCAM Gene family reagents (Blood group antigens)

Approved Symbol Reagent list
ABO
ART4
CD44
CD59
GYPA
ICAM4
Approved Symbol Reagent list
ACHE
BSG
CD55
CD99
GYPC
XG

BCAM Gene family reagents (CD molecules)

Approved Symbol Reagent list
LIFR
SIGLEC5
NECTIN1
PDGFRB
CD38
PVR
TNFRSF12A
CD160
KLRC1
CD99
Approved Symbol Reagent list
IL6ST
IL2RA
CDCP1
CD300E
CD79B
ALCAM
CD9
ICAM2
TNFRSF10B
NECTIN3

BCAM Gene family reagents (C2-set domain containing)

Approved Symbol Reagent list
CADM1
CD22
BTN3A1
CADM3
CRTAM
CADM4
CD4
CADM2
MCAM
KIRREL2
Approved Symbol Reagent list
ICOSLG
CD200R1
SIGLEC10
CD2
KIRREL3
ALCAM
VCAM1
CD276
TMEM25
NECTIN1

BCAM Gene family reagents (Immunoglobulin like domain containing)

Approved Symbol Reagent list
MCAM
FCRL2
AMIGO2
CD84
CD160
ESAM
IL18R1
MERTK
KIT
PVR
Approved Symbol Reagent list
FCGR1A
IL1RL2
LAIR1
LY9
IL11RA
CADM3
ALCAM
LEPR
JAM3
SLAMF6

BCAM Gene family reagents (Ig-like cell adhesion molecule family)

Approved Symbol Reagent list
NECTIN1
CADM3
CD84
CD47
SLAMF1
CD2
CNTN3
CD244
CADM1
NFASC
Approved Symbol Reagent list
ROBO2
CNTN4
LRRC4C
CADM2
ICAM5
CD28
CRTAM
THY1
CNTN1
JAM2

BCAM cDNA / Gene Alias

  • CD239

BCAM cDNA / Gene Expression

Broad expression in kidney (RPKM 99.8), prostate (RPKM 62.6) and 19 other tissues