A4GALT Protein Overview: Sequence, Structure, Function and Protein Interaction

A4GALT Protein Overview

The A4GALT gene encodes alpha-1,4-galactosyltransferase (EC, an enzyme that transfers a galactose to the alpha-1,4 position of lactosylceramide to form globotriaosylceramide (GB3), also known as CD77. This glycolipid has been characterized on red blood cells as the P(k) antigen of the P1PK blood group system (111400). The A4GALT gene also synthesizes the P1 antigen of the P1PK blood group system (Iwamura et al., 2003, Thuresson et al., 2011).

A4GALT protein family

Belongs to the glycosyltransferase 32 family.

A4GALT protein name

Recommended name
Lactosylceramide 4-alpha-galactosyltransferase
A14GALT, CD77 synthase, Gb3 synthase, Gb3S, globotriaosylceramide synthase, lactosylceramide 4-alpha-galactosyltransferase, P(k)
Alternative name
Alpha-1,4-N-acetylglucosaminyltransferase Alpha-1,4-galactosyltransferase Alpha4Gal-T1 CD77 synthase Globotriaosylceramide synthase P1/Pk synthase UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase

A4GALT Protein Sequence

Species Human A4GALT protein
Length 353
Mass (Da) 40499
Sequence Human A4GALT protein sequence
Species Mouse A4GALT protein
Length 359
Mass (Da) 41366
Sequence Mouse A4GALT protein sequence
Species Rat A4GALT protein
Length 360
Mass (Da) 41551
Sequence Rat A4GALT protein sequence

A4GALT Protein Molecular Weight & PI

Lactosylceramide 4-alpha-galactosyltransferase (EC (Alpha-1,4-N-acetylglucosaminyltransferase) (Alpha-1,4-galactosyltransferase) (Alpha4Gal-T1) (CD77 synthase) (Globotriaosylceramide synthase) (Gb3 synthase) (P1/Pk synthase) (UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-353 Lactosylceramide 4-alpha-

Molecular weight (Da)


Theoretical pI


A4GALT Protein Interaction

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