zika virus treatment

Treatment for Zika virus

Till now, there are specific treatments for Zika virus infection. There are no available antiviral vaccines, no drugs and other treatment. In order to avoiding some adverse effects, such as hepatopathy, allergy and nephropathy, people should use analgesics and antipyretic agents carefully. The use of aspirin should be avoided in order to prevent the induction of bleeding disorders in patients with dengue misdiagnosed with Zika virus infection due to an inconclusive clinical diagnosis and to an unreliable serological analysis.

Treatment for severe pruritus caused by Zika virus

The severe pruritus that follows the rash has been described by patients as an intense discomfort. The approach to pruritic rash may start with the recommendation that patients should avoid hot baths, the excessive use of soap and use adequate skin moisturisers. When these are not successful, cold baths and the use of refreshing lotions with calamine or menthol is recommended. The pathogenesis of skin manifestations is still unclear and thu the use of older antihistamine agents may benefit the patient due to the sedative action rather than to some direct action on the cause of pruritus. Topic corticosteroids should be avoided as their efficacy on this symptom is unknown.

Treatment for GBS

GBS should be conventionally approached. Diagnosis is established when the patient presents with progressive weakness affecting two or more limbs, areflexia and clinical progression in up to four weeks. Cerebrospinal fluid (CSF) analysis may show protein increase and low cellularity (albuminocytologic dissociation). Patients with suspected GBS should be monitored in intensive care units due to the risk of progression to respiratory muscle paralysis. Therapeutic options include plasmapheresis or hyperimmune IVIG (hyperimmune immunoglobulin): both reduce time to recovery despite being expensive therapies.

Zika virus treatment related reference

1. Nelwan EJ, Pohan HT. Dengue convalescent rash in adult Indonesian patients. Acta Med Indones. 2014;46:339-40.
2. Simmons CP, Farrar JJ, Nguyen V, Wills B. Dengue. N Engl J Med. 2012;366:1423-32.
3. Ansar V, Valadi N. Guillain-Barré syndrome. Prim Care. 2015;42:189-93.
4,Pinto Júnior VL, et al. Zika virus: a review to clinicians, Acta Med Port 2015 Nov-Dec;28(6):760-765