H6N5 subtype is commonly perpetuated in its natural hosts and is of concern due to its potential to be a precursor of highly pathogenic influenza viruses by reassortment. The migratory waterfowl of the world are considered to be the natural reservoir of influenza A viruses. Researchers have isolated a H6N5 virus productively infected mice with no evidence of adaptation which could cause illness and lethality. With further study, they found that this H6N5 virus could infect both mice and ferret, but not in pigs. The isolate showed less efficient replication and transmission and failed to trigger clinical symptoms in birds (ducks and chicken).
Here we list some hot research strains of H6N5.