Cell Adhesion Receptors as Drug Targets

Cell Adhesion Receptors as Drug Target Background

Cell adhesion receptors are transmembrane receptors that mediate cell adhesion to neighboring cells and to the extracellular matrix. The crucial role of adhesion receptors signaling in tumor cells as well as in stromal cells that support cancer growth, metastasis, and therapy resistance indicates that adhesion receptors signaling may be an attractive drug target for cancer therapy strategies.

Cell adhesion receptors are key sensors of cues that stem from the environment, thereby contributing to both the adhesive process and to transmission of signals that result in dependent cellular responses.

Indeed, adhesion receptors can modulate or activate intracellular signal transduction pathways in a number of ways, for example, by clustering in the membrane at adhesion sites, by recruiting and interacting with adaptor proteins or proteins that link adhesive structures to cellular cytoskeletal networks, or by directly activating enzymatic proteins at the inner surface of the plasma membrane. In addition to stimulating signal transduction pathways, adhesion receptors are themselves subject to regulation by intracellular signalling (often termed 'inside-out' signalling).

Integrin Cell Adhesion Receptors as Drug Target

Drug Target HGNC-approved name
ITGA1 Integrin, alpha 1
ITGA2 Integrin, alpha 2 (alpha 2 subunit of VLA-2 receptor)
ITGA2B Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex)
ITGA3 Integrin, alpha 3 (alpha 3 subunit of VLA-3 receptor)
ITGA4 Integrin, alpha 4 (alpha 4 subunit of VLA-4 receptor)
ITGA5 Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 Integrin, alpha 6
ITGA7 Integrin, alpha 7
ITGA8 Integrin, alpha 8
ITGA9 Integrin, alpha 9
ITGA10 Integrin, alpha 10
ITGA11 Integrin, alpha 11
ITGAD Integrin, alpha D
ITGAE Integrin, alpha E (antigen CD103)
ITGAL Integrin, alpha L (antigen CD11A (p180))
ITGAM Integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAV Integrin, alpha V
ITGAX Integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB1 Integrin, beta 1 (fibronectin receptor)
ITGB1BP1 Integrin beta 1‐binding protein 1
ITGB2 Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 Integrin, beta 4
ITGB5 Integrin, beta 5
ITGB6 Integrin, beta 6
ITGB7 Integrin, beta 7
ITGB8 Integrin, beta 8

Cadherin Cell Adhesion Receptors as Drug Target

Drug Target HGNC-approved name
CDH1 Cadherin 1, type 1, E‐cadherin (epithelial)
CDH2 Cadherin 2, type 1, N‐cadherin (neuronal)
CDH3 Cadherin 3, type 1, P‐cadherin (placental)
CDH4 Cadherin 4, type 1, R‐cadherin (retinal)
CDH5 Cadherin 5, type 2 (vascular endothelium)
CDH6 Cadherin 6, type 2, K‐cadherin (fetal kidney)
CDH8 Cadherin 8, type 2
CDH11 Cadherin 11, type 2, OB‐cadherin (osteoblast)
CDH12 Cadherin 12, type 2 (N‐cadherin 2)
CDH13 Cadherin 13
CDH15 Cadherin 15, type 1, M‐cadherin (myotubule)
CDH16 Cadherin 16, KSP‐cadherin
CDH17 Cadherin 17, LI cadherin (liver‐intestine)
CDH18 Cadherin 18, type 2
CDH19 Cadherin 19, type 2
CDH24 Cadherin 24, type 2
CDH26 Cadherin 26