Like other TGF-beta superfamily receptors members, activin receptor, transduces signals through type I and II receptor serine/threonine kinases. The binding of activins to activin type IIA (ActRIIA) or type IIB (ActRIIB) receptors induces the recruitment and phosphorylation of an activin type I receptor (ALK4 and/or ALK7), which then phosphorylates the Smad 2 and Smad 3 intracellular signaling proteins.
There are mainly two types of activin receptors. Type I activin receptors include ACVR1B and ACVR1C. Type II activin receptors include ACVR2A, ACVR2B and BMPR2.
Activin receptor and other TGF-beta superfamily receptors members signaling through Smad 2 and 3 were found to maintain human embryonic stem cell (hESC) pluripotency and self-renewal and that blocking activin signaling resulted in hESC differentiation.
Activin Receptor Products List
* Being developed. Tell us your requirement so that the products of interest be placed on the priority list.
- Receptors Classification
- Cytokine Receptors
- • Chemokine Receptor
- • Interferon/IFN Receptor
- • TNF Receptor
- • CSF Receptor
- • Interleukin Receptor
- • TGF-beta Superfamily Receptors
- - Activin Receptor
- - BMP Receptor
- - GDNF Receptor
- - TGF-beta Family Receptor
- Receptors by Differentiation Cells
- Receptors by Drug Target
- Receptors by Functions
- Receptors Reagent Products
- Receptors by Species
