What is adoptive immunotherapy for cancer? Adoptive immunotherapy for cancer is a treatment used to help the immune system fight cancer. T cells are collected from a patient and grown in the laboratory. This increases the number of T cells that are able to kill cancer cells. These T cells are given back to the patient to help the immune system fight disease. Also called cellular adoptive immunotherapy.
The early promise of adoptive immunotherapy is now coming to fruition with exciting clinical responses being reported against various cancers. This has particularly been the case with adoptive transfer of tumor-infiltrating lymphocytes in patients with advanced malignant melanoma, transfer of chimeric antigen receptor (CAR) T cells targeting CD19 in patients with B-cell malignancies such as chronic lymphoid leukemia and acute lymphoblastic leukemia and transfer of Epstein–Barr virus (EBV)-specific T cells against viral-induced malignancies such as post-transplant lymphoproliferative disorder(PTLD).
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