Her2/ERBB2 Protein, Human, Recombinant (ECD, domain IV, His Tag)


Her2/ERBB2 Protein, Human, Recombinant (ECD, domain IV, His Tag): Product Information

> 85 % as determined by SDS-PAGE
< 1.0 EU per μg protein as determined by the LAL method.
1.Measured by its binding ability in a functional ELISA.
2.Immobilized human ErbB2 (Cat:10004-H08H4) at 10μg/mL (100μL/well) can bind herceptin ,the EC50 of herceptin is 10-40ng/mL.
Protein Construction
A DNA sequence encoding the human ERBB2 (NP_004439.2) (Pro489-Cys630) was expressed with a polyhistidine tag at the C-terminus.
Expressed Host
HEK293 Cells
Predicted N Terminal
Pro 489
Molecule Mass
The recombinant human ERBB2 consists of 153 amino acids and predicts a molecular mass of 17.1 kDa. As a result of glycosylation, human ErbB2 migrates as an approximately 27 kDa protein in SDS-PAGE under reducing conditions.
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Her2/ERBB2 Protein, Human, Recombinant (ECD, domain IV, His Tag): Images

Measured by its binding ability in a functional ELISA.  Immobilized human ErbB2 (Cat: 10004-H08H4) at 10 μg/mL (100 μL/well) can bind herceptin, the EC50 of herceptin is 10-40 ng/mL.

Her2/ERBB2 Protein, Human, Recombinant (ECD, domain IV, His Tag): Synonyms

CD340 Protein, Human; ENV Protein, Human; ENVW Protein, Human; ERVWE1 Protein, Human; HER-2 Protein, Human; HER-2/neu Protein, Human; HER2 Protein, Human; HERV-7q Protein, Human; HERV-W-ENV Protein, Human; HERV7Q Protein, Human; HERVW Protein, Human; HERVWENV Protein, Human; MLN 19 Protein, Human; MLN19 Protein, Human; NEU Protein, Human; NGL Protein, Human; TKR1 Protein, Human

Her2/ERBB2 Background Information

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
Full Name
erb-b2 receptor tyrosine kinase 2
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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